Launch from the Baikonur Cosmodrome as replacement for the damaged spacecraft Soyuz MS-22. Soyuz MS-23 was launched unmanned to bring back the crew of Soyuz MS-22.

Soyuz MS-23 delivered 429 kg of cargo to the ISS for the crew of the 68^th and 69^th Expedition. Among them are the means of medical control and examination, cleaning the station and monitoring the purity of the atmosphere, ensuring the gas composition, water supply and equipment for scientific experiments "Interaction-2", "Matryoshka-R", "Cardiovector" , "MSK-2", "Cascade", "Fagen" and "Probiovit".
The unmanned spacecraft also brought back-up equipment for the systems of the Russian segment of the station, means of landing, maintenance and repairs, crew support, prevention of the adverse effects of weightlessness, sanitation and hygiene supplies, protection of astronauts from adverse effects, laundry and containers with food rations.

Soyuz MS-23 docked on February 26, 2023 at 00:58:00 UTC to the International Space Station.